1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 23155264, compound

Participants

Reaction Steps

In 5 mL of methylene chloride, 37 mg of N-(4-imidazo[4,5-c]pyridin-1-yl-phenyl)hydroxylamine obtained in Step A was dissolved, and 41 mg (1.84 mmol) of 4-chloro-3-(trifluoromethyl)phenyl isocyanate was added thereto and the mixture solution was stirred at room temperature for three hours. The reaction solution was concentrated, and then the residue was partitioned between ethyl acetate and a saturated ammonium chloride aqueous solution. The organic layer was washed with a saturated sodium chloride solution, dried and concentrated under reduced pressure. The residue was triturated with n-hexane:ethyl acetate=1:1 to obtain 12 mg (16%) of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxy-3-(4-imidazo-[4,5-c]pyridin-1-ylphenyl)urea (Table 1, Compound No. 45) as a white solid.

Provenance & Evidence