p-Fluoronitrobenzene → HCID 23155159, compound

HRID 1912791Notes

Reaction equation

HRID 1912791 reaction equation
[CH3:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.F[C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=O)=[CH:14][CH:13]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][C:23]=1[C:31]([F:34])([F:33])[F:32]>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:30])[N:18]([OH:20])[C:15]2[CH:14]=[CH:13][C:12]([N:6]3[CH:5]=[N:4][C:3]4[C:7]3=[N:8][CH:9]=[N:10][C:2]=4[CH3:1])=[CH:17][CH:16]=2)=[CH:24][C:23]=1[C:31]([F:32])([F:33])[F:34]

Participants

4

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 52875471H-Purine, 6-methyl-

Product 1

HCID 23155159HCID 23155159, compound

Procedure

The title compound can be synthesized from 6-methylpurine, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)phenyl isocyanate by using the same techniques as in Example 45.

Sources & evidence

ORD record
ord-ff6ec0975c0a4a0ca6f0712396e1e647
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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