Morpholine → HCID 23154944, compound

HRID 1912793Notes

Reaction equation

HRID 1912793 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C:11]1[CH:16]=[CH:15][C:14]([N:17]([OH:32])[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=2)=[O:19])=[CH:13][CH:12]=1.[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([NH:20][C:18]([N:17]([OH:32])[C:14]2[CH:15]=[CH:16][C:11]([N:6]3[CH:5]=[N:4][C:3]4[C:7]3=[N:8][CH:9]=[N:10][C:2]=4[N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)=[CH:12][CH:13]=2)=[O:19])=[CH:22][C:23]=1[C:28]([F:30])([F:31])[F:29]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 23154956HCID 23154956, compound

Product 1

HCID 23154944HCID 23154944, compound

Procedure

The title compound can be synthesized from 1-[4-(6-chloropurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)-phenyl)-1-hydroxyurea and morpholine by using the same techniques as in Example 53.

Sources & evidence

ORD record
ord-caf86236a31741628be3da6581d5f744
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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