2-(Methylamino)ethanol → HCID 23155132, compound

HRID 1912794Notes

Reaction equation

HRID 1912794 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C:11]1[CH:16]=[CH:15][C:14]([N:17]([OH:32])[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=2)=[O:19])=[CH:13][CH:12]=1.[CH3:33][NH:34][CH2:35][CH2:36][OH:37]>>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([NH:20][C:18]([N:17]([OH:32])[C:14]2[CH:15]=[CH:16][C:11]([N:6]3[CH:5]=[N:4][C:3]4[C:7]3=[N:8][CH:9]=[N:10][C:2]=4[N:34]([CH2:35][CH2:36][OH:37])[CH3:33])=[CH:12][CH:13]=2)=[O:19])=[CH:22][C:23]=1[C:28]([F:29])([F:31])[F:30]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 23154956HCID 23154956, compound

Product 1

HCID 23155132HCID 23155132, compound

Procedure

The title compound can be synthesized from 1-[4-(6-chloropurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)-1-hydroxyurea and 2-methylamino-ethanol by using the same techniques as in Example 53.

Sources & evidence

ORD record
ord-19708b0e5d63453f9f3e321d03688fe8
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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