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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1912797Generated: November 3, 2026

Acetic Anhydride → N-(1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)-3-hydroxyureido]phenyl}-1H-indol-5-yl)acetamide

https://huagongshe.com/reaction/1912797

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AnhydrideHCID 7918—
ReactantHCID 23155046HCID 23155046—
ProductN-(1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)-3-hydroxyureido]phenyl}-1H-indol-5-yl)acetamideHCID 23155214—

Reaction Steps

The title compound can be synthesized from 1-[4-(5-aminoindol-1-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)-3-hydroxyurea hydrochloride and acetic anhydride by using the same techniques as in Example 41.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08609656B2
Source datasetuspto-grants-2013_12
ORD IDord-7d975284f73a4e55a1f19d36ee3a5e73
Source noteuspto-grants-2013_12