Hydrogen Peroxide → HCID 23155151, compound

Participants

Reaction Conditions

Reaction Steps

In 15 mL of acetic acid, 483 mg (2.01 mmol) of 1-(4-nitrophenyl)-1H-imidazo[4,5-c]pyridine prepared in Step A of Example 1 was dissolved, and 2 mL of a 30% hydrogen peroxide aqueous solution was added thereto and the mixture solution was stirred at 50° C. for 14 hours. The solvent was distilled under reduced pressure, and the obtained residue was separated by a silica gel column (Si-10, a product of Kusano Co., Ltd., column 30 cm, dichloromethane:methanol=9:1) to obtain 298 mg (57%) of 1-(4-nitrophenyl)-1H-imidazo[4,5-c]pyridine 5-oxide as a pale yellow solid.

Provenance & Evidence