Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → N-(9-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl)-2-methylaminoacetamide hydrochloride
Reaction equation
Cl.[NH2:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=2)=[O:20])=[CH:14][CH:13]=1.C(O[C:38]([N:40]([CH2:42][C:43](O)=[O:44])C)=O)(C)(C)C>>[ClH:28].[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([NH:21][C:19](=[O:20])[NH:18][C:15]2[CH:14]=[CH:13][C:12]([N:7]3[CH:6]=[N:5][C:4]4[C:8]3=[N:9][CH:10]=[N:11][C:3]=4[NH:2][C:43](=[O:44])[CH2:42][NH:40][CH3:38])=[CH:17][CH:16]=2)=[CH:23][C:24]=1[C:29]([F:31])([F:32])[F:30]Participants
3
Reactant 2
Product 1
Procedure
The titled compound can be synthesized from 1-[4-(6-aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride and tert-butoxycarbonyl-sarcosine by using the same method as in Example 96.
Sources & evidence
- ORD record
- ord-e3f2f9ff376448c2b887a4053aef97e9
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08609656B2
Reaction notes
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