HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-(2-Methoxyethoxy)ethoxy]acetyl chloride → N-(9-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl)-2-[2-(2-methoxyethoxy)ethoxy]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-(2-Methoxyethoxy)ethoxy]acetyl chloride | HCID 2759571 | — |
| Reactant | 1-[4-(6-Aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride | HCID 23155120 | — |
| Product | N-(9-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl)-2-[2-(2-methoxyethoxy)ethoxy]acetamide | HCID 23155113 | — |
Reaction Steps
The title compound can be synthesized from 1-[4-(6-aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride and 2-[2-(2-methoxyethoxy)ethoxy]acetyl chloride by using the same method as in Example 107.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609656B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-34294b315371412494be04a27e823772 |
| Source note | uspto-grants-2013_12 |