2-Chloroethyl chloroformate → 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-{4-[6-(2-oxo-oxazolidin-3-yl)purin-9-yl]phenyl}urea

HRID 1912830Notes

Reaction equation

HRID 1912830 reaction equation
Cl.[NH2:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[N:5]=[CH:6][N:7]2[C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[C:24]([C:29]([F:32])([F:31])[F:30])[CH:23]=2)=[O:20])=[CH:14][CH:13]=1.Cl[C:34]([O:36][CH2:37][CH2:38]Cl)=[O:35]>>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([NH:21][C:19]([NH:18][C:15]2[CH:14]=[CH:13][C:12]([N:7]3[CH:6]=[N:5][C:4]4[C:8]3=[N:9][CH:10]=[N:11][C:3]=4[N:2]3[CH2:38][CH2:37][O:36][C:34]3=[O:35])=[CH:17][CH:16]=2)=[O:20])=[CH:23][C:24]=1[C:29]([F:31])([F:32])[F:30]

Participants

3

Reactant 2

HCID 123052-Chloroethyl chloroformateHCID 231551201-[4-(6-Aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride

Product 1

HCID 231551991-(4-Chloro-3-(trifluoromethyl)phenyl)-3-{4-[6-(2-oxo-oxazolidin-3-yl)purin-9-yl]phenyl}urea

Procedure

The title compound can be synthesized from 1-[4-(6-aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride and 2-chloroethyl chloroformate by using the same method as in Example 107.

Sources & evidence

ORD record
ord-46f13ca311ee42ba84a0c4158dddaa4a
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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