HCID 59725890, compound → HCID 69314303, compound

Participants

Reaction Steps

In 2 mL of a 4N hydrogen chloride ethyl acetate solution, 13 mg (0.02 mmol) of (9-{4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl]carbamic acid 2-(tert-butoxycarbonylamino)ethyl ester was dissolved and the solution was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure, and then the residue was triturated with n-hexane:ethyl acetate=1:1, collected by filtration and vacuum dried to obtain 1.7 mg (16%) of (9-{4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-ylcarbamic acid 2-(methylamino)ethyl ester hydrochloride as a white solid.

Provenance & Evidence