2-(Methylamino)ethanol → HCID 23155232, compound

HRID 1912838Notes

Reaction equation

HRID 1912838 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.[CH3:11][NH:12][CH2:13][CH2:14][OH:15].F[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[CH:29][C:28]=1[C:36]([F:39])([F:38])[F:37]>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][C:34]([NH:23][C:20]2[CH:21]=[CH:22][C:17]([N:6]3[CH:5]=[N:4][C:3]4[C:7]3=[N:8][CH:9]=[N:10][C:2]=4[N:12]([CH2:13][CH2:14][OH:15])[CH3:11])=[CH:18][CH:19]=2)=[O:35])=[CH:29][C:28]=1[C:36]([F:37])([F:38])[F:39]

Participants

5

Reactant 4

HCID 80162-(Methylamino)ethanolHCID 9590p-FluoronitrobenzeneHCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 53592776-Chloropurine

Product 1

HCID 23155232HCID 23155232, compound

Procedure

The title compound can be synthesized from 6-chloro-purine, 2-(methylamino)ethanol, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)phenyl isocyanate by using the same techniques as in Example 35.

Sources & evidence

ORD record
ord-a32440b7424548189becfb30dab584ef
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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