Tributylvinyltin → HCID 11363485, compound

Participants

Reaction Conditions

Reaction Steps

In 2 mL of dimethylformamide, 158 mg (0.28 mmol) of 1-[4-(6-amino-8-iodopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea was dissolved, and 262 mg (0.82 mmol) of vinyltributyltin and 20 mg (0.01 mmol) of tetrakistriphenylphosphine palladium was added thereto and the mixture solution was stirred at 95° C. for three hours. The reaction solution was concentrated and purified by a silica gel column (dichloromethane:methanol=9:1) to obtain 122 mg (93%) of a target product as a white solid.

Provenance & Evidence