HCID 11363485, compound → HCID 23154929, compound

Participants

Reaction Steps

In a mixed solution of 4 mL of tetrahydrofuran and 1 mL of water, 20 mg (0.04 mmol) of 1-[4-(6-amino-8-vinyl-purin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)-urea was dissolved, and 20 μL of a 0.1 M osmium tetraoxide aqueous solution and 40 mg (0.19 mmol) of sodium periodate were added thereto and the mixture solution was stirred at room temperature for 14 hours. The reaction solution was concentrated under reduced pressure and purified by a silica gel column (dichloromethane:methanol=9:1) to obtain 18 mg (90%) of a target product as a white crystal.

Provenance & Evidence