Water → HCID 23154978, compound

Participants

Reaction Conditions

Reaction Steps

In 30 mL of acetic acid, 1 g (2.23 mmol) of 1-[4-(6-aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea and 0.8 g (9.75 mmol) of sodium acetate were dissolved and to the solution, 0.7 g (4.38 mmol) of bromine was added dropwise and the mixture solution was stirred at 50° C. for one hour. To the reaction solution, 40 mL of water was added, and the deposited product was collected by filtration, and recrystallized from ethanol to obtain 1.095 g (93%) of a target product as a white solid.

Provenance & Evidence