2-Methoxyethanol → HCID 23155211, compound

HRID 1912848Notes

Reaction equation

HRID 1912848 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5](I)[N:6]2[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=2)=[O:19])=[CH:13][CH:12]=1.[CH3:33][O:34][CH2:35][CH2:36][OH:37]>>[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:37][CH2:36][CH2:35][O:34][CH3:33])[N:6]2[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=2)=[O:19])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 23155066HCID 23155066, compound

Product 1

HCID 23155211HCID 23155211, compound

Procedure

The title compound can be prepared from 1-[4-(6-amino-8-iodopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea and 2-methoxyethanol by using the same techniques as in Example 136.

Sources & evidence

ORD record
ord-ff4cb312ae78475fa1601c37a3135f5b
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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