6-Chloropurine → HCID 178482413, compound

HRID 1912853Notes

Reaction equation

HRID 1912853 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.CO.[CH3:13][NH2:14]>C(O)C>[CH3:13][NH:14][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][NH:6]2

Participants

4

Reactant 2

HCID 53592776-ChloropurineHCID 57454252Monomethylamine methanol

Product 1

HCID 178482413HCID 178482413, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

In 20 mL of a 40% methylamine methanol solution and 20 mL of ethanol, 12.5 g (79 mmol) of 6-chloropurin was dissolved and the solution was sealed in a tube and stirred in the tube at 120° C. for four hours. The reaction solution was concentrated, and then triturated with water and collected on a filter, washed with water, and then vacuum dried to obtain 10.78 g (90%) of methyl-(9H-purin-6-yl)amine as a white solid.

Workup

  1. customthe solution was sealed in a tube
  2. concentrationThe reaction solution was concentrated
  3. customtriturated with water
  4. customcollected on a filter
  5. washwashed with water
  6. customvacuum dried

Sources & evidence

ORD record
ord-1302be8d5de74e82b3de355c27ec8ea5
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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