methyl-[9-(4-nitrophenyl)-9H-purin-6-yl]amine → [9-(4-aminophenyl)-9H-purin-6-yl]-methylamine

Participants

Reaction Steps

In 1,000 mL of methanol, 13.0 g (48 mmol) of methyl-[9-(4-nitrophenyl)-9H-purin-6-yl]amine was suspended, and 1.8 g of 10% palladium carbon was added thereto, and the suspension was stirred in a hydrogen atmosphere at 60° C. for six hours. The palladium carbon was removed by Celite filtration, and the product was concentrated under reduced pressure, and the obtained crude product was purified by a silica gel column (ethyl acetate:methanol=9.1) to obtain 8.2 g (70%) of a target product as a pale yellow solid.

Provenance & Evidence