反应详情

In 1,000 mL of methanol, 13.1 g (51 mmol) of [9-(4-nitrophenyl)-9H-purin-6-yl]amine was suspended, and 1.0 g of 10% palladium carbon was added thereto and the mixture suspension was stirred at 60° C. for 22 hours in a hydrogen atmosphere. The palladium carbon was removed by Celite filtration and the filtrate was washed with 3 L of hot methanol. The methanol solution was concentrated under reduced pressure and the formed product was purified by a silica gel column (ethyl acetate:methanol=8:1) to obtain 10.29 g (89%) of a target product as a pale yellow solid.

1. customThe palladium carbon was removed by Celite filtration
2. washthe filtrate was washed with 3 L of hot methanol
3. concentrationThe methanol solution was concentrated under reduced pressure
4. customthe formed product was purified by a silica gel column (ethyl acetate:methanol=8:1)