Morpholine → 1-[4-(6-(Methylamino)purin-9-yl)phenyl]-3-(4-morpholin-4-ylmethyl-3-(trifluoromethyl)phenyl)urea

HRID 1912867Notes

Reaction equation

HRID 1912867 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O[C:12](=O)[N:13]([C:15]1[N:23]=[CH:22][N:21]=[C:20]2[C:16]=1[N:17]=[CH:18][N:19]2[C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][C:34]2[CH:39]=[CH:38][C:37]([CH:40]=O)=[C:36]([C:42]([F:45])([F:44])[F:43])[CH:35]=2)=[O:32])=[CH:26][CH:25]=1)C)(C)(C)C>>[CH3:12][NH:13][C:15]1[N:23]=[CH:22][N:21]=[C:20]2[C:16]=1[N:17]=[CH:18][N:19]2[C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][C:34]2[CH:39]=[CH:38][C:37]([CH2:40][N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[C:36]([C:42]([F:45])([F:44])[F:43])[CH:35]=2)=[O:32])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 59725906(9-{4-[3-(4-formyl-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl)-methylcarbamic acid tert-butyl ester

Product 1

HCID 231552001-[4-(6-(Methylamino)purin-9-yl)phenyl]-3-(4-morpholin-4-ylmethyl-3-(trifluoromethyl)phenyl)urea

Procedure

The title compound can be prepared from morpholine and (9-{4-[3-(4-formyl-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl)-methyl-carbamic acid tert-butyl ester by the same techniques as in Example 168.

Sources & evidence

ORD record
ord-a0609a6d45ce4948809cb990d924497d
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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