HRID1912867

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

结构：CN(C(=O)OC(C)(C)C)c1ncnc2c1ncn2-c1ccc(NC(=O)Nc2ccc(C=O)c(C(F)(F)F)c2)cc1

HCID59725906

未命名化合物

PRODUCTS

生成物

结构：CNc1ncnc2c1ncn2-c1ccc(NC(=O)Nc2ccc(CN3CCOCC3)c(C(F)(F)F)c2)cc1

HCID23155200

未命名化合物

PROCEDURE

实验过程

The title compound can be prepared from morpholine and (9-{4-[3-(4-formyl-3-(trifluoromethyl)phenyl)ureido]phenyl}-9H-purin-6-yl)-methyl-carbamic acid tert-butyl ester by the same techniques as in Example 168.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a0609a6d45ce4948809cb990d924497d
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08609656B2
来源说明: uspto-grants-2013_12

反应 SMILES

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O[C:12](=O)[N:13]([C:15]1[N:23]=[CH:22][N:21]=[C:20]2[C:16]=1[N:17]=[CH:18][N:19]2[C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][C:34]2[CH:39]=[CH:38][C:37]([CH:40]=O)=[C:36]([C:42]([F:45])([F:44])[F:43])[CH:35]=2)=[O:32])=[CH:26][CH:25]=1)C)(C)(C)C>>[CH3:12][NH:13][C:15]1[N:23]=[CH:22][N:21]=[C:20]2[C:16]=1[N:17]=[CH:18][N:19]2[C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][C:34]2[CH:39]=[CH:38][C:37]([CH2:40][N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[C:36]([C:42]([F:45])([F:44])[F:43])[CH:35]=2)=[O:32])=[CH:26][CH:25]=1