反应详情

In a microwave vessel containing the product from Example 1B (0.4 g, 1.549 mmol) and 3-(dimethylamino)acrylaldehyde (0.155 g, 1.549 mmol) in ethanol (5 mL) was added two drops of acetic acid. The mixture was irradiated with microwave at 140° C. for 15 minutes and concentrated. The resulting solid was purified by flash chromatography on silica gel, eluting with EtOAc/Hexanes (40-70% gradient), to yield the title compound (0.49 g, 59%). MS ESI+ m/z 295.5 [M+H]+.

1. customThe mixture was irradiated with microwave at 140° C. for 15 minutes
2. concentrationconcentrated
3. customThe resulting solid was purified by flash chromatography on silica gel
4. washeluting with EtOAc/Hexanes (40-70% gradient)