2-Pyridineacetic acid, hydrochloride (1:1) → N-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-2-yl]-2-(pyridin-2-yl)acetamide

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Reaction Steps

2-Pyridylacetic acid hydrochloride (44 mg, 0.25 mmol) and the product from Example 99A (62 mg, 0.25 mmol) were processed as described in Example 98 to afford 41 mg (45%) of the title compound. 1H NMR (400 MHz, CD3OD) δ ppm 8.85 (dd, J=7.0, 1.7 Hz, 1H), 8.55 (dd, J=4.1, 1.7 Hz, 1H), 8.47-8.53 (m, 1H), 7.77-7.86 (m, 1H), 7.68-7.71 (m, 2H), 7.40-7.48 (m, 1H), 7.31-7.40 (m, 3H), 7.05 (dd, J=7.0, 4.1 Hz, 1H), 3.97 (s, 2H); MS (ESI) m/z 364 (M+H)+; Anal. calculated for C19H14ClN5O: C, 62.73; H, 3.88; N, 19.25. Found C, 62.65; H, 3.65; N, 19.19.

Provenance & Evidence