反应详情

3-Pyridylacetic acid hydrochloride and the product from Example 99A were processed using method analogous to that described in Example 98 to afford the title compound. 1H NMR (400 MHz, CD3OD) δ ppm 8.85 (dd, J=7.0, 1.8 Hz, 1H), 8.55 (dd, J=4.1, 1.8 Hz, 1H), 8.52-8.55 (m, 1H), 8.46-8.50 (m, 1H), 7.78-7.89 (m, 1H), 7.60-7.64 (m, 2H), 7.37-7.45 (m, 1H), 7.29-7.32 (m, 2H), 7.06 (dd, J=7.0, 4.1 Hz, 1H), 3.81 (s, 2H); MS (ESI) m/z 364 (M+H)+; Anal. calculated for C19H14ClN5O.0.35H2O: C, 61.66; H, 4.00; N, 18.92. Found C, 61.40; H, 3.70; N, 18.77.