HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Dimethoxyphenyl)acetic acid → N-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-2-yl]-2-(3,5-dimethoxyphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Dimethoxyphenyl)acetic acid | HCID 138316 | — |
| Reactant | 3-(4-Chlorophenyl)pyrazolo[1,5-a]pyrimidin-2-amine | HCID 68751295 | — |
| Product | N-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-2-yl]-2-(3,5-dimethoxyphenyl)acetamide | HCID 68748701 | 8% |
Reaction Steps
3,5-Dimethoxyphenylacetic acid and the product from Example 99A were processed using the method analogous to that described in example 98 to afford 9 mg (8%) of the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.36-10.57 (bs, 1H), 9.10 (dd, J=6.9, 1.7 Hz, 1H), 8.62 (dd, J=4.1, 1.7 Hz, 1H), 7.66-7.70 (m, 2H), 7.29-7.32 (m, 2H), 7.14 (dd, J=6.9, 4.1 Hz, 1H), 6.47-6.56 (bs, 2H), 6.44 (s, 1H), 3.73 (s, 6H), 3.58 (s, 2H); MS (ESI) m/z 423 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609669B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-0d0af6b18fb84e40b5d62145880db3c6 |
| Source note | uspto-grants-2013_12 |