trans-2-(4-Chlorophenyl)vinylboronic acid → N-{3-[(E)-2-(4-chlorophenyl)vinyl]pyrazolo[1,5-a]pyrimidin-2-yl}-3,3-dimethylbutanamide

Participants

Reaction Steps

The product from Example 110B and trans-2-(4-chlorophenyl)vinylboronic acid were processed using the method analogous to that described in Example 110C to afford the title compound. H NMR (400 MHz, CD3OD) δ ppm 8.80 (dd, J=7.0, 1.7 Hz, 1H), 8.60 (dd, J=4.1, 1.6 Hz, 1H), 7.65 (d, J=16.3 Hz, 1H), 7.47-7.50 (m, 2H), 7.31-7.34 (m, 2H), 7.19 (d, J=16.5 Hz, 1H), 7.03 (dd, J=7.0, 4.1 Hz, 1H), 2.41-2.41 (bs, 2H), 1.17 (s, 9H); MS (ESI) m/z 369 (M+H)+.

Provenance & Evidence