Benzenepropanoyl chloride → HCID 68755615, compound

HRID 1912930Notes

Reaction equation

[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[C:15]1([CH2:21][CH2:22][C:23](Cl)=[O:24])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:1]([C:5]1[C:6]([NH:14][C:23](=[O:24])[CH2:22][CH2:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 64801Benzenepropanoyl chloride

HCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68755615HCID 68755615, compound

Procedure

The product from Example 105B and 3-phenylpropionyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.40 (s, 9H), 2.56-2.67 (m, 2H), 2.90 (t, J=7.6 Hz, 2H), 6.99 (dd, J=7.0, 3.9 Hz, 1H), 7.17-7.31 (m, 5H), 8.48 (dd, J=4.1, 1.7 Hz, 1H), 8.92 (dd, J=7.1, 1.7 Hz, 1H), 9.74 (s, 1H); MS (DCI) m/z 323 (M+H)+.

Sources & evidence

ORD record: ord-d452659cc3574b49bfe3eeff62cdc375
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609669B2

Reaction notes

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