Cyclohexylpropionyl chloride → HCID 68748385, compound

HRID 1912934Notes

Reaction equation

[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:15]1([CH2:21][CH2:22][C:23](Cl)=[O:24])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[C:1]([C:5]1[C:6]([NH:14][C:23](=[O:24])[CH2:22][CH2:21][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 2734098Cyclohexylpropionyl chloride

HCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68748385HCID 68748385, compound

Procedure

The product from Example 105B and 3-cyclohexylpropionyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.81-0.93 (m, 2H), 1.05-1.31 (m, 4H), 1.44-1.52 (m, 11H), 1.57-1.78 (m, 5H), 2.24-2.35 (m, 2H), 6.99 (dd, J=6.7, 4.0 Hz, 1H), 8.48 (dd, J=4.0, 1.6 Hz, 1H), 8.92 (dd, J=6.9, 1.8 Hz, 1H), 9.66 (s, 1H); MS (DCI) m/z 329 (M+H)+; EA calculated for C19H28N4O: C, 69.48; H, 8.59; N, 17.06. Found: C, 69.41; H, 8.33; N, 16.89.

Sources & evidence

ORD record: ord-67e9396964a24429a169353cf9db6912
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609669B2

Reaction notes

Loading…