反应详情

温度

70 °C

The product from Example 133B (0.33 g, 2.29 mmol) was taken up in thionyl chloride (4 mL, 54.8 mmol) and heated at 70° C. for 1 hour. The reaction mixture was cooled to room temperature and concentrated under vacuum. The residue was taken up in CH2Cl2 (5 mL) and concentrated again to remove excess thionyl chloride. This was repeated twice more. The residue was dissolved in CH2Cl2 (2.5 mL) to provide a solution of the title compound that was used for the next step.

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationconcentrated under vacuum
3. concentrationconcentrated again
4. customto remove excess thionyl chloride
5. dissolutionThe residue was dissolved in CH2Cl2 (2.5 mL)