2-(4-Fluorophenyl)acetic acid → N-(3-bromopyrazolo[1,5-a]pyrimidin-2-yl)-2-(4-fluorophenyl)acetamide

HRID 1912943Notes

Reaction equation

HRID 1912943 reaction equation
[Br:1][C:2]1[C:3]([NH2:11])=[N:4][N:5]2[CH:10]=[CH:9][CH:8]=[N:7][C:6]=12.[F:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20](O)=[O:21])=[CH:15][CH:14]=1>>[Br:1][C:2]1[C:3]([NH:11][C:20](=[O:21])[CH2:19][C:16]2[CH:17]=[CH:18][C:13]([F:12])=[CH:14][CH:15]=2)=[N:4][N:5]2[CH:10]=[CH:9][CH:8]=[N:7][C:6]=12

Participants

3

Reactant 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 68750728HCID 68750728, compound

Product 1

HCID 68749921N-(3-bromopyrazolo[1,5-a]pyrimidin-2-yl)-2-(4-fluorophenyl)acetamide

Procedure

The product from Example 110A and 4-fluorophenylacetic acid were processed using the method analogous to that described in Example 137 to provide the title compound. MS (APCI) m/z 349/351 (M+H)+.

Sources & evidence

ORD record
ord-403a34614dca4710afbee300baeaaab3
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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