4-(Trifluoromethoxy)phenylboronic acid → 2-(4-fluorophenyl)-N-{3-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-2-yl}acetamide

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Reaction Steps

The product from Example 140A and 4-trifluoromethoxyphenylboronic acid were processed using the method analogous to that described in example 110C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.29-10.76 (bs, 1H), 9.11 (dd, J=6.9, 1.7 Hz, 1H), 8.63 (dd, J=4.1, 1.7 Hz, 1H), 7.75-7.78 (m, 2H), 7.32-7.39 (m, 2H), 7.24-7.29 (m, 2H), 7.14-7.19 (m, 3H), 3.67 (s, 2H); MS (APCI) m/z 431 (M+H)+. Anal. calculated for C21H14F4N4O2: C, 58.61; H, 3.28; N, 13.02. Found C, 58.37; H, 2.91; N, 12.81.

Provenance & Evidence