Thionyl Chloride → HCID 86665181, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 143B (6.56 g) was combined with thionyl chloride (50 mL, 685 mmol) and the reaction mixture was heated at 70° C. for 2 hours. The reaction mixture was concentrated under vacuum, and the residue was dissolved in CHCl3 (50 mL) and concentrated again to remove excess thionyl chloride. The residue was distilled under vacuum (air bath 100-110° C./˜10 mm) to provide the title compound, used directly for the next step.

Provenance & Evidence