3-(4-(Trifluoromethyl)phenyl)propionic Acid → N-(3-tert-butylpyrazolo[1,5-a]pyrimidin-2-yl)-3-[4-(trifluoromethyl)phenyl]propanamide

Participants

Reaction Steps

The product from Example 105B and 4-(trifluoromethyl)hydrocinnamic acid were processed using the method analogous to that described in Example 137 to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.36 (s, 9H), 2.61-2.73 (m, 2H), 3.00 (t, J=7.5 Hz, 2H), 6.99 (dd, J=7.1, 4.1 Hz, 1H), 7.78-7.51 (m, 2H), 7.63-7.66 (m, 2H), 8.48 (dd, J=4.1, 1.7 Hz, 1H), 8.91 (dd, J=7.1, 1.7 Hz, 1H), 9.75 (s, 1H); MS (DCI) m/z 391 (M+H)+.

Provenance & Evidence