4-Isopropylphenylacetic acid → HCID 68749189, compound

HRID 1912964Notes

Reaction equation

HRID 1912964 reaction equation
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:15]([C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](O)=[O:26])=[CH:20][CH:19]=1)([CH3:17])[CH3:16]>>[C:1]([C:5]1[C:6]([NH:14][C:25](=[O:26])[CH2:24][C:21]2[CH:22]=[CH:23][C:18]([CH:15]([CH3:16])[CH3:17])=[CH:19][CH:20]=2)=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 782304-Isopropylphenylacetic acidHCID 687554713-Tert-butylpyrazolo[1,5-a]pyrimidin-2-amine

Product 1

HCID 68749189HCID 68749189, compound

Procedure

The product from Example 105B and 4-isopropylphenylacetic acid were processed using the method analogous to that described in Example 137 to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.7 Hz, 3H), 1.39 (s, 9H), 2.82-2.91 (m, 1H), 3.58 (s, 2H), 6.99 (dd, J=7.1, 4.0 Hz, 1H), 7.18-7.23 (m, 4H), 8.48 (dd, J=4.0, 2.0 Hz, 1H), 8.91 (dd, J=7.0, 2.0 Hz, 1H), 9.91 (s, 1H); MS (DCI) m/z 351 (M+H)+.

Sources & evidence

ORD record
ord-a1f8f02d32b54ced96d7a2cf1975681c
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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