3-Cyclopentylpropionyl chloride → HCID 68750982, compound

HRID 1912975Notes

Reaction equation

HRID 1912975 reaction equation
[C:1]([C:5]1[C:6]([NH2:15])=[N:7][N:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:16]1([CH2:21][CH2:22][C:23](Cl)=[O:24])[CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:1]([C:5]1[C:6]([NH:15][C:23](=[O:24])[CH2:22][CH2:21][CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[N:7][N:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 660393-Cyclopentylpropionyl chlorideHCID 68751373HCID 68751373, compound

Product 1

HCID 68750982HCID 68750982, compound

Procedure

The product from Example 178A and 3-cyclopentylpropionyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.04-1.15 (m, 2H), 1.43-1.81 (m, 18H), 2.26-2.30 (m, 5H), 8.38 (d, J=2.0 Hz, 1H), 8.75 (s, 1H), 9.62 (br s, 1H); MS (DCI) m/z 329 (M+H)+.

Sources & evidence

ORD record
ord-7432cbcb1e3a417faa4cc23fe2926be7
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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