2-Chloropyridine-5-boronic acid → N-[3-(6-chloropyridin-3-yl)pyrazolo[1,5-a]pyrimidin-2-yl]-2-(4-fluorophenyl)acetamide

Participants

Reaction Steps

The product from Example 140A and 2-chloropyridine-5-boronic acid were processed using the method analogous to that described in Example 110C to provide the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.48-10.92 (bs, 1H), 9.13 (dd, J=7.0, 1.7 Hz, 1H), 8.72 (d, J=1.9 Hz, 1H), 8.65 (dd, J=4.2, 1.7 Hz, 1H), 8.05 (dd, J=8.5, 2.2 Hz, 1H), 7.43 (d, J=8.3 Hz, 1H), 7.32-7.36 (m, 2H), 7.13-7.19 (m, 3H), 3.69 (s, 2H); MS (APCI) m/z 382 (M+H)+.

Provenance & Evidence