Benzyl Bromide → [[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropoxy)ethoxy]phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methoxy]-tert-butyl-dim-ethyl-silane

Participants

Reaction Conditions

Reaction Steps

(2S,3R,4S,5S,6R)-6-[(tert-butyl(dimethyl)silyl)oxymethyl]-2-[4-chloro-3-[[4-[2-(cyclopropoxy)ethoxy]phenyl]methyl]phenyl]-2-methoxy-tetrahydropyran-3,4,5-triol 1b (3.0 g, 4.92 mmol) was dissolved in 50 mL N,N-dimethyl formamide and cooled to 0° C. 60% NaH (984 mg, 24.6 mmol) was added. Then the reaction mixture was warmed to room temperature and stirred for 15 minutes before benzyl bromide (2.95 mL, 24.6 mmol) was added. The mixture was stirred for 16 hours. The reaction mixture was concentrated under reduced pressure after 5 mL methanol were added. The residue was dissolved in 100 mL ethyl acetate and partitioned. The organic extracts were washed with water (50 mL×2) and combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure obtain the crude title compound [[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropoxy)ethoxy]phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methoxy]-tert-butyl-dim-ethyl-silane 1c (4.26 g, yellow grease), which was used directly without purification in the next step.

Provenance & Evidence