Acetyl chloride → HCID 68015075, compound

Participants

Reaction Steps

[[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-(2,3-dihydrobenzofuran-5-ylmethyl)phenyl]-6-methoxy-tetrahydropyran-2-yl]tert-butyl-dimethyl-methoxy]silane 5g (11.86 g, 14.4 mmol) was dissolved in 100 mL methanol, followed by addition of acetyl chloride (152 μL, 2.17 mmol). The reaction mixture was stirred for 1 hour and concentrated under reduced pressure and the resulting residue was purified by silica gel chromatography with elution system D to obtain the title compound [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-(2,3-dihydrobenzofuran-5-ylmethyl)phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol 5h (9.0 g, yellow liquid), yield: 88.1%.

Provenance & Evidence