HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1913068Generated: November 1, 2026
Dimethylformamide → 5-Bromo-2-chlorobenzoyl chloride
https://huagongshe.com/reaction/1913068
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromo-2-chlorobenzoic acid | HCID 33127 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Bromo-2-chlorobenzoyl chloride | HCID 2756871 | 94.1% |
Reaction Steps
Under Ar protection, 5-bromo-2-chloro-benzoic acid (35 g, 148.6 mmol) was dissolved in toluene (230 ml), followed by addition of DMF (0.5 mL) at room temperature, then the reaction mixture was cooled to 0° C. The reaction mixture was heated to 100° C. after thionyl chloride (44 g, 372 mmol) was dropwise added. After 5 hours, the reaction mixture was concentrated under reduced pressure to obtain the title compound 5-bromo-2-chloro-benzoyl chloride 12n (35.5 g, pale yellow grease), yield: 94.0%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08609622B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-48e8c9d894ed47ae9467c92bcdb29e80 |
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| Source note | uspto-grants-2013_12 |
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