3-Bromo-4-fluorobenzaldehyde → 6-Fluoro-7-bromoisoquinoline

HRID 1913109Notes

Reaction equation

HRID 1913109 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.FC1C=C2C(=CC=1)C=[N:17][CH:16]=[CH:15]2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:7]([CH:15]=[CH:16][N:17]=[CH:5]2)=[CH:8][C:9]=1[F:10]

Participants

3

Reactant 2

HCID 1736043-Bromo-4-fluorobenzaldehydeHCID 218898476-Fluoroisoquinoline

Product 1

HCID 534029646-Fluoro-7-bromoisoquinoline

Procedure

Starting from 3-bromo-4-fluoro-benzaldehyde, the title compound was prepared by the same reaction sequence as used for the synthesis of 6-fluoro-isoquinoline (3). Rt=0.91 min (Method B). Detected mass: 226.0/228.0 (M+H+).

Sources & evidence

ORD record
ord-30bd2b488e2e45b8a6acc9065cf20349
Source dataset
uspto-grants-2013_12
Patent number
US08609691B2

Reaction notes

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