Hydrochloric Acid → 6-Fluoro-2-(piperidin-4-yl)-1H-benzimidazole

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-(5-fluoro-1H-benzimidazol-2-yl)piperidine-1-carboxylate (0.81 g, 2.53 mmol) in DCM (8 mL) is added a solution of 4M HCl in dioxane (2 mL). The reaction mixture is stirred at room temperature for 18 h. The reaction mixture is concentrated under reduced pressure to give 0.74 g of 5-fluoro-2-(piperidin-4-yl)-1H-benzimidazole. This product is used in the next step without further purification.

Provenance & Evidence