tert-Butyl 3-(1H-imidazol-2-yl)azetidine-1-carboxylate → 2-(azetidin-3-yl)-1H-imidazole

Participants

Reaction Steps

To a stirred solution of tert-butyl 3-(1H-imidazol-2-yl)azetidine-1-carboxylate (36 mg, 0.16 mmol) in DCM (1 mL) is added boron trifluoride diethyl ether complex (40 μL, 0.318 mmol). After 2 h the reaction mixture is quenched with water (11 μL). MeOH is added and the reaction mixture is concentrated under reduced pressure to give crude 2-(azetidin-3-yl)-1H-imidazole.

Provenance & Evidence