Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1913159생성일: 2026년 10월 25일
3,4-Diaminopyridine → biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone
https://huagongshe.com/reaction/1913159
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3,4-Diaminopyridine | HCID 5918 | — |
| 반응물 | Triphenyl Phosphate | HCID 8289 | — |
| 반응물 | 1-([1,1'-Biphenyl]-4-carbonyl)piperidine-4-carboxylic acid | HCID 893053 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone | HCID 178519408 | 27.8% |
반응 단계
To a mixture of 1-(biphenyl-4-ylcarbonyl)piperidine-4-carboxylic acid (0.10 g, 0.32 mmol) and 3,4-diaminopyridine (35 mg, 0.32 mmol) in pyridine (1 mL) is added triphenyl phosphate (0.10 mL, 0.38 mmol). The mixture is heated under microwave irradiation at 120° C. for 50 mins. Purification by preparative HPLC gives 34 mg of biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08609696B2 |
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| 출처 데이터셋 | uspto-grants-2013_12 |
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| ORD ID | ord-372b6ab6863c4d32aaf284a40ee14b9c |
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| 출처 메모 | uspto-grants-2013_12 |
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