HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 178485282, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | HCID 178497345 | HCID 178497345 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178485282 | HCID 178485282 | — |
Reaction Steps
A solution of methyl 2-[1-(biphenyl-4-ylcarbonyl)piperidin-4-yl]-1H-benzimidazole-5-carboxylate (30 mg, 0.068 mmol) in 2M methylamine in EtOH (1 mL) is heated in at 50° C. for 18 h. The reaction is concentrated under reduced pressure and purified by preparative HPLC to give 13 mg of 2-[1-(biphenyl-4-ylcarbonyl)piperidin-4-yl]-N-methyl-1H-benzimidazole-5-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609696B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-230a41872a784083802791c6a94121ab |
| Source note | uspto-grants-2013_12 |