Methyl 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}piperidine-4-carboxylate → 1-{[4-(Pyridin-2-yl)phenyl]sulfonyl}piperidine-4-carboxylic acid

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Reaction Steps

A stirred solution of methyl 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}piperidine-4-carboxylate (0.25 g, 0.69 mmol) in 5M aqueous HCl (2.5 mL) is heated at 80° C. for 18 h. The mixture is cooled to room temperature resulting in formation of a precipitate. The precipitate is filtered, washed sequentially with 5M aqueous HCl and MeCN and dried in air to give 0.10 g (44%) of 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}piperidine-4-carboxylic acid. m/z=347 [M++H].

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