反应详情

To a stirred solution of methyl 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}piperidine-4-carboxylate (0.40 g, 1.11 mmol) in anhydrous methanol (8 mL) is added sodium borohydride (0.59 g, 15.5 mmol). After 18 h water (20 mL) is added. The resulting solid is filtered, washed with water and suspended in MeCN. The suspension is concentrated under reduced pressure to give 0.26 g (72%) of 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}piperidin-4-yl)methanol. m/z=333 [M++H].

1. filtrationThe resulting solid is filtered
2. washwashed with water
3. concentrationThe suspension is concentrated under reduced pressure
4. customto give 0.26 g (72%) of 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}piperidin-4-yl)methanol