Water → HCID 58494558, compound

Participants

Reaction Steps

To a stirred solution of methyl 1-{[4-(pyridin-2-yl)phenyl]sulfonyl}azetidine-3-carboxylate (0.33 g, 0.99 mmol) in anhydrous methanol (20 mL) is added sodium borohydride (0.25 g, 6.58 mmol) portionwise. After 30 mins water (40 mL) is added followed by 5N aqueous NaOH. The aqueous layer is extracted with DCM. The organic layer is dried over Na2SO4, filtered and concentrated under reduced pressure to give 0.22 g (72%) of (1-{[4-(pyridin-2-yl)phenyl]sulfonyl}azetidin-3-yl)methanol. m/z=305 [M++H].

Provenance & Evidence