HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-Hydrazinylpyridine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Chloro-4-cyanopyridine | HCID 568638 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Hydrazinylpyridine-4-carbonitrile | HCID 20118714 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
20.0 g (144 mmol) of 2-chloroisonicotinonitrile are initially charged in 150 ml of 1-butanol, 303 ml (303 mmol) of a 1 M solution of hydrazine hydrate in THF are added and the mixture is heated for 16 h (bath temperature 110° C.). The mixture is concentrated and the residue is purified by flash chromatography on silica gel (mobile phase: dichloromethane/methanol 10:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609698B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-4b56da6c308746fb9d985a66ec02c867 |
| Source note | uspto-grants-2013_12 |