2-Hydrazinylpyridine-4-carbonitrile → HCID 68704935, compound

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Reaction Steps

545 mg (4.06 mmol) of the compound from Example 1A and 1.07 g (4.88 mmol) of the compound from Example 2A in 15 ml of glacial acetic acid are stirred at RT for 2 h. The mixture is concentrated and the residue is taken up in 300 ml of ethyl acetate and washed repeatedly with saturated sodium bicarbonate solution. The organic phase is dried over sodium sulfate, filtered and concentrated. The residue is taken up in 30 ml of ethanol, 1.33 g (4.88 mmol) of a 25% strength solution of sodium ethoxide in ethanol are added at RT and the mixture is stirred for 30 min. The pH is adjusted to 5 by addition of 1 M hydrochloric acid, and the solid formed is filtered off with suction, washed with diethyl ether and dried under high vacuum.

Provenance & Evidence