Hydrazine hydrate (1:1) → N-[(6-Hydrazinopyridin-3-yl)methyl]-2-methoxyethanamine

Participants

Reaction Steps

3.6 g (17.7 mmol) of N-[(6-chloropyridin-3-yl)methyl]-2-methoxyethanamine [prepared analogously to WO 2004/081007] are initially charged in 4.3 ml (4.4 g, 88.5 mmol) of hydrazine hydrate and stirred at boiling point at a bath temperature of 150° C. for 16 h. The reaction solution is cooled and concentrated, and the residue is purified by column chromatography on silica gel (mobile phase: acetonitrile/water 9:1).

Provenance & Evidence