Hydrazine hydrate (1:1) → 2-Hydrazino-5-(methanesulfonyl)-pyridine

Participants

Reaction Conditions

Reaction Steps

1.7 ml (1.7 g, 34.0 mmol) of hydrazine hydrate are added to 2.0 g (8.5 mmol) of 2,5-bis(methylsulfonyl)pyridine [Woods et al., J. Heterocycl. Chem. 1984, 21, 97-101] in 15 ml of ethanol, and the mixture is stirred under reflux for 4 h. For work-up, the reaction solution is cooled to 15° C., the precipitated solid is filtered off, the filter residue is washed with ethanol and diethyl ether and the product is dried under reduced pressure.

Provenance & Evidence