Hydrazine hydrate (1:1) → 2-Hydrazinyl-4-methylpyridine

Participants

Reaction Steps

3.3 g (30.0 mmol) of 2-fluoro-4-methylpyridine are initially charged in 40 ml of ethylene glycol monoethyl ether, 14.6 ml (15.0 g, 300 mmol) of hydrazine hydrate are added to the solution and the mixture is stirred at boiling point (bath temperature 150° C.) for 16 h. The reaction solution is then concentrated on a rotary evaporator, and the residue is added to 100 ml of water and extracted with ethyl acetate (three times 100 ml each). The combined organic phases are dried over sodium sulfate, filtered and concentrated. The residue obtained is dried under reduced pressure.

Provenance & Evidence